Following the completion of the human genome, the quantity and utility of genetic data has increased enormously. Among its many applications is the use by both defendants and plaintiffs in personal injury litigation. Information on the genetic susceptibilities that an individual was born with often is relevant for determining fault or alternative causation in a toxic tort case. Chromosomal breaks or changes in an individual’s gene sequences or gene expression can be relevant for proving or disproving causation. Genetic evidence has now been introduced into hundreds of personal injury cases. This presentation will discuss the legal, policy and ethical implications of such evidence.